About NORTRIPTYLINE

NORTRIPTYLINE belongs to a group of medicines called 'tricyclic antidepressants' primarily used to treat
depression. Additionally, it is also used to treat neuropathic pain and bedwetting at night. Depression is a
mental illness or disorder characterized by persistently depressed mood or loss of interest in activities,
causing significant impairment in daily life.

NORTRIPTYLINE contains Nortriptyline that works by affecting certain chemical messengers (serotonin,
norepinephrine) in the brain which communicate between brain cells, thereby regulating mood and preventing
depression. Besides this, NORTRIPTYLINE also the transmission of pain signals, thereby provides relief from
neuropathic pain.

Take NORTRIPTYLINE as prescribed by your doctor. You are advised to take NORTRIPTYLINE for as long as
your doctor has prescribed it for you depending on your medical condition and response to the treatment. In
some cases, you may experience certain common side-effects such as increased heart rate, ushing,
drowsiness, weight gain, difculty in urination, orthostatic hypotension (sudden lowering of blood pressure on
standing), dryness in the mouth, tingling in the arms or legs, blurred vision (dilated pupils). Most of these
side-effects do not require medical attention and will resolve gradually over time. However, you are advised to
talk to your doctor if you experience these side-effects persistently.

To treat your condition effectually, continue taking NORTRIPTYLINE for as long as your doctor has prescribed.
Inform your doctor if you have suicidal ideation or behaviour symptoms, heart disease, seizure disorders,
.glaucoma, thyroid problems, kidney and liver problems. Do not take NORTRIPTYLINE if you are pregnant or
breastfeeding unless prescribed by the doctor. The safety and effectiveness in children less than 18 years of
age have not been established, so NORTRIPTYLINE should not be given to them. Avoid consuming alcohol along
with NORTRIPTYLINE as it could lead to increased drowsiness and dizziness. Consult your doctor immediately
if you have suicidal thoughts such as killing or harming yourself. Rise slowly from sitting or lying position as
NORTRIPTYLINE causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on
standing). Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Uses of NORTRIPTYLINE
Depression

Medicinal Benefits
NORTRIPTYLINE belongs to a group of medicines called tricyclic antidepressants used to prevent depression. It
works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain which communicate
between brain cells, thereby helps in regulating mood and treats depression. NORTRIPTYLINE prevents the
transmission of pain signals, thereby provides relief from neuropathic pain.

Directions for Use
Oral tablet/capsule: Take NORTRIPTYLINE with or without food as advised by your doctor and swallow whole
with a glass of water. Do not crush, chew or break it. Liquid oral syrup: Shake the bottle before use. Check the
label for directions and take NORTRIPTYLINE with or without food in dose as prescribed by your doctor with the
help of a measuring cup.

Storage
Store in a cool and dry place away from sunlight

Side Effects of NORTRIPTYLINE
~ Increased heart rate
~ Flushing
~ Drowsiness
~ Weight gain
~ Difficulty in urination
~ Constipation
~ Orthostatic hypotension (sudden lowering of blood pressure on standing)
~ Dryness in the mouth
~ Tingling in the arms or legs
~ Blurred vision

Drug Warnings
Do not take NORTRIPTYLINE if you are known to be allergic to NORTRIPTYLINE. Inform your doctor if you
have suicidal ideation or behaviour symptoms, have heart rhythm problems or hypotension, heart disease,
seizure disorders, bone marrow suppression, diabetes, schizophrenia, bipolar disorder, acute alcohol
intoxication, glaucoma, thyroid problems, kidney and liver problems. Do not take NORTRIPTYLINE if you are
pregnant or breastfeeding unless prescribed by the doctor. NORTRIPTYLINE should not be given to the children
less than 18 years of age, as its safety and efcacy have not been established. Avoid consuming alcohol along
with NORTRIPTYLINE as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying
position as NORTRIPTYLINE causes orthostatic hypotension (sudden lowering in blood pressure leading to
dizziness on standing).

Drug Interactions
Drug-Drug Interaction : NORTRIPTYLINE may have interaction with monoamine oxidase inhibitors (medicines
used to treat depression) (moclobemide, phenelzine, iproniazid, isocarboxazid, nialamide, tranylcypromine,
selegiline) medicine to treat high blood pressure (diltiazem, verapamil, guanethidine, debrisoquine, bethanidine,
clonidine, reserpine, methyldopa ) pain killers (tramadol, trazodone, hydrocodone, oxycodone, acetaminophen),
antidepressant (bupropion, duloxetine, uoxetine, sertraline), antihistamine (diphenhydramine, cetirizine),
sedatives (zolpidem), muscle relaxant (cyclobenzaprine), medicines to treat fungal infections (uconazole,
terbinane, ketoconazole, and itraconazole), anti-thyroid (levothyroxine).
Drug- Food Interaction : Avoid St. John ́s Wort (a herbal remedy used for depression) and alcohol as it may
increase the risk of side effects when taken along with NORTRIPTYLINE..
Drug-Disease Interaction : If you have vaginal bleeding or discharge, difculty in urination, fever, constipation,
blood in stools, myasthenia gravis (muscle weakness), anxiety disorders, depression, schizophrenia, manic
depression, sleep apnoea (breathing stops and starts repeatedly during sleep), spinal or cerebral ataxia, kidney
or liver problems, inform your doctor before taking CHLORDIAZEPOXIDE+MEBEVERINE.

Safety Advice

ALCOHOL CONSULT YOUR DOCTOR
Avoid consumption of alcohol while taking NORTRIPTYLINE as it may cause an increased
sedative effect. Please consult a doctor before consuming alcohol with NORTRIPTYLINE.

PREGNANCY CONSULT YOUR DOCTOR
Consult your doctor before taking NORTRIPTYLINE; your doctor will decide whether
NORTRIPTYLINE can be taken by breastfeeding mothers or not.

BREAST FEEDING CONSULT YOUR DOCTOR
Consult your doctor before taking NORTRIPTYLINE; your doctor will decide whether
NORTRIPTYLINE can be taken by breastfeeding mothers or not.
DRIVING
NORTRIPTYLINE may affect your ability to drive or operate machinery safely. Therefore,
drive only if you are alert after taking NORTRIPTYLINE.

LIVER
Take NORTRIPTYLINE with caution, especially if you have a history of liver disease/
conditions. The dose may be adjusted by your doctor as required.

KIDNEY
Dose adjustment may be needed in patients with kidney impairment. Please consult
your doctor if you have kidney impairment or any concerns regarding this.

Habit Forming
No

Diet & Lifestyle Advise
~ Maintain a healthy diet and exercise regularly helps in improving overall health and boosts self-esteem.
~ Regularly attend therapy sessions.
~ Perform meditation and yoga. This helps in relieving stress and provides relaxation.
~ Follow a regular sleep pattern to improve the amount and quality of sleep you get.
~ Include foods rich in omega fatty acids such as sh, nuts, fresh fruits, vegetables and olive oils.
~ Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products and
certain fruits and vegetables help in the proper maintenance of neurotransmitters.
~ Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole
grains, legumes, spinach, broccoli, oranges and pears.
~ Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress,
improving mood, boosts self-esteem and provides restful sleep.
~ Avoid smoking and alcohol consumption.
~ Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Special Advise
NORTRIPTYLINE may increase the risk of suicidal thoughts and behavior for people younger than 24 years.
If you have symptoms of suicidal ideation or behavior, please consult your doctor before taking
NORTRIPTYLINE.
Do not use NORTRIPTYLINE if you have used an MAO inhibitor in the past 14 days, as a dangerous drug
interaction could occur.
NORTRIPTYLINE may increase your risk of seizures. If you have a history of seizures, your doctor will
monitor you more closely.

Nortriptyline Hydrochloride Tablets I.P. 10 mg
Px

TRIPODEP-N 10
Ta b l e t s
TM

4 x 5 x 10 Tablets
TRIPODEP-N 10
Ta b l e t s
TM

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